Quantitative Systems Pharmacology (QSP) modeling is essential for drug development but it requires significant time investment that limits the throughput of domain experts. We present \textbf{GRASP} -- a multi-agent, graph-reasoning framework with a human-in-the-loop conversational interface -- that encodes QSP models as typed biological knowledge graphs and compiles them to executable MATLAB/SimBiology code while preserving units, mass balance, and physiological constraints. A two-phase workflow -- \textsc{Understanding} (graph reconstruction of legacy code) and \textsc{Action} (constraint-checked, language-driven modification) -- is orchestrated by a state machine with iterative validation. GRASP performs breadth-first parameter-alignment around new entities to surface dependent quantities and propose biologically plausible defaults, and it runs automatic execution/diagnostics until convergence. In head-to-head evaluations using LLM-as-judge, GRASP outperforms SME-guided CoT and ToT baselines across biological plausibility, mathematical correctness, structural fidelity, and code quality (\(\approx\)9--10/10 vs.\ 5--7/10). BFS alignment achieves F1 = 0.95 for dependency discovery, units, and range. These results demonstrate that graph-structured, agentic workflows can make QSP model development both accessible and rigorous, enabling domain experts to specify mechanisms in natural language without sacrificing biomedical fidelity.

Long-video understanding remains a significant challenge for Multimodal Large Language Models (MLLMs) due to inherent token limitations and the complexity of capturing long-term temporal dependencies. Existing methods often fail to capture the global context and complex event relationships necessary for deep video reasoning. To address this, we introduce GCAgent, a novel Global-Context-Aware Agent framework that achieves comprehensive long-video understanding. Our core innovation is the Schematic and Narrative Episodic Memory. This memory structurally models events and their causal and temporal relations into a concise, organized context, fundamentally resolving the long-term dependency problem. Operating in a multi-stage Perception-Action-Reflection cycle, our GCAgent utilizes a Memory Manager to retrieve relevant episodic context for robust, context-aware inference. Extensive experiments confirm that GCAgent significantly enhances long-video understanding, achieving up to 23.5\% accuracy improvement on the Video-MME Long split over a strong MLLM baseline. Furthermore, our framework establishes state-of-the-art performance among comparable 7B-scale MLLMs, achieving 73.4\% accuracy on the Long split and the highest overall average (71.9\%) on the Video-MME benchmark, validating our agent-based reasoning paradigm and structured memory for cognitively-inspired long-video understanding.

Identifying whether two product listings refer to the same Stock Keeping Unit (SKU) is a persistent challenge in ecommerce, especially when explicit identifiers are missing and product names vary widely across platforms. Rule based heuristics and keyword similarity often misclassify products by overlooking subtle distinctions in brand, specification, or bundle configuration. To overcome these limitations, we propose Question to Knowledge (Q2K), a multi agent framework that leverages Large Language Models (LLMs) for reliable SKU mapping. Q2K integrates: (1) a Reasoning Agent that generates targeted disambiguation questions, (2) a Knowledge Agent that resolves them via focused web searches, and (3) a Deduplication Agent that reuses validated reasoning traces to reduce redundancy and ensure consistency. A human in the loop mechanism further refines uncertain cases. Experiments on real world consumer goods datasets show that Q2K surpasses strong baselines, achieving higher accuracy and robustness in difficult scenarios such as bundle identification and brand origin disambiguation. By reusing retrieved reasoning instead of issuing repeated searches, Q2K balances accuracy with efficiency, offering a scalable and interpretable solution for product integration.

AI has proven highly successful at urban planning analysis -- learning patterns from data to predict future conditions. The next frontier is AI-assisted decision-making: agents that recommend sites, allocate resources, and evaluate trade-offs while reasoning transparently about constraints and stakeholder values. Recent breakthroughs in reasoning AI -- CoT prompting, ReAct, and multi-agent collaboration frameworks -- now make this vision achievable. This position paper presents the Agentic Urban Planning AI Framework for reasoning-capable planning agents that integrates three cognitive layers (Perception, Foundation, Reasoning) with six logic components (Analysis, Generation, Verification, Evaluation, Collaboration, Decision) through a multi-agents collaboration framework. We demonstrate why planning decisions require explicit reasoning capabilities that are value-based (applying normative principles), rule-grounded (guaranteeing constraint satisfaction), and explainable (generating transparent justifications) -- requirements that statistical learning alone cannot fulfill. We compare reasoning agents with statistical learning, present a comprehensive architecture with benchmark evaluation metrics, and outline critical research challenges. This framework shows how AI agents can augment human planners by systematically exploring solution spaces, verifying regulatory compliance, and deliberating over trade-offs transparently -- not replacing human judgment but amplifying it with computational reasoning capabilities.

Large Language Models (LLMs) trained with reinforcement learning and verifiable rewards have achieved strong results on complex reasoning tasks. Recent work extends this paradigm to a multi-agent setting, where a meta-thinking agent proposes plans and monitors progress while a reasoning agent executes subtasks through sequential conversational turns. Despite promising performance, we identify a critical limitation: lazy agent behavior, in which one agent dominates while the other contributes little, undermining collaboration and collapsing the setup to an ineffective single agent. In this paper, we first provide a theoretical analysis showing why lazy behavior naturally arises in multi-agent reasoning. We then introduce a stable and efficient method for measuring causal influence, helping mitigate this issue. Finally, as collaboration intensifies, the reasoning agent risks getting lost in multi-turn interactions and trapped by previous noisy responses. To counter this, we propose a verifiable reward mechanism that encourages deliberation by allowing the reasoning agent to discard noisy outputs, consolidate instructions, and restart its reasoning process when necessary. Extensive experiments demonstrate that our framework alleviates lazy agent behavior and unlocks the full potential of multi-agent framework for complex reasoning tasks. Techniques such as chain-of-thought prompting (Wei et al., 2022; Kojima et al., 2022) and structured methods like Tree-of-Thoughts and Graph-of-Thoughts (Y ao et al., 2023; Besta et al., 2024) expand the space for deliberation. More recently, multi-agent frameworks enable LLMs with specialized roles to collaborate via planning, delegation, and debate, echoing human team dynamics (Li et al., 2023; Wu et al., 2024a; Chen et al., 2023; Du et al., 2023; Y uan & Xie). To support multi-agent and multi-turn reinforcement learning, multi-turn Group Relative Preference Optimization (GRPO) (Wan et al., 2025; Shi et al., 2025; Wei et al., 2025) and its variants (Guo et al., 2025b; Zhang et al., 2025c; Ning et al., 2025; Xue et al., 2025) compute advantages and importance ratios at the turn level, enabling finer-grained optimization and more precise credit assignment. Building on this foundation, ReMA (Wan et al., 2025) introduces a multi-agent LLM reasoning framework with two specialized roles: a meta-thinking agent, which decomposes tasks, sets intermediate goals, and adapts based on feedback, and a reasoning agent, which performs step-by-step 1 The agents alternate sequentially, but since only a final outcome reward is available, ReMA computes a group advantage following GRPO (Shao et al., 2024) and uniformly assigns this trajectory-level signal to every turn in the rollout.

Recent advances in text-only large language models (LLMs), such as DeepSeek-R1, demonstrate remarkable reasoning ability. However, these models remain fragile or entirely incapable when extended to multi-modal tasks. Existing approaches largely rely on single-form captions, which lack diversity and often fail to adapt across different types of Visual Question Answering (VQA) benchmarks. As a result, they provide no principled or efficient channel for transmitting fine-grained visual information. We introduce Seeing Eye, a modular framework that unlocks multimodal reasoning in text-only LLMs through an agent-based small VLM translator. This translator acts as a perception agent: it can invoke specialized tools (e.g., OCR and crop) and iteratively distill multimodal inputs into structured intermediate representations (SIRs) tailored to the question. These SIRs are then passed to the text-only LLM, which serves as a reasoning agent. Crucially, the translator and reasoner engage in multi-round feedback and interaction, enabling the extraction of targeted visual details and yielding more confident answers. Experiments on knowledge-intensive VQA benchmarks, including MMMU and MIA-Bench, demonstrate that Seeing Eye not only reduces inference cost but also surpasses much larger end-to-end VLMs. For example, an instantiation combining a 3B-parameter vision translator with an 8B-parameter language reasoner outperforms a monolithic 32B VLM on challenging knowledge-based questions. Our results highlight that decoupling perception from reasoning via agent information flow offers a scalable and plug-and-play pathway to multimodal reasoning, allowing strong text-only LLMs to fully leverage their reasoning capabilities. Code is available at: https://github.com/ulab-uiuc/SeeingEye

Recent progress in multi-agent systems highlights the promise of specialized agents that collaborate through a division of labor. In contrast, most tool-augmented reasoning systems still adopt a single-agent paradigm, where one large model must interleave high-level reasoning with fine-grained tool operations--a process that often leads to cognitive-load interference and unstable outputs. We propose MSARL (Multi-Small-Agent Reinforcement Learning), a novel framework that explicitly decouples reasoning from tool execution and interpretation. In MSARL, a dedicated reasoning agent focuses on strategic problem decomposition and planning, while a specialized tool agent processes long and complex tool outputs, acting as an adaptive condenser to bridge information gaps. This role-specific separation not only reduces cognitive interference but also accelerates the information flow. To enable effective collaboration, we introduce a hierarchical reinforcement learning approach that uses role-specific and collaboration-based rewards, providing granular feedback to the tool agent and a holistic, trajectory-level signal to the reasoning agent. On mathematical problem-solving with code execution, MSARL achieves more stable reasoning and higher final-answer accuracy than strong single-agent baselines.

Multi-hop claim verification is inherently challenging, requiring multi-step reasoning to construct verification chains while iteratively searching for information to uncover hidden bridging facts. This process is fundamentally interleaved, as effective reasoning relies on dynamically retrieved evidence, while effective search demands reasoning to refine queries based on partial information. To achieve this, we propose Hierarchical Agent Reasoning and Information Search (HARIS), explicitly modeling the coordinated process of reasoning-driven searching and search-informed reasoning. HARIS consists of a high-level reasoning agent that focuses on constructing the main verification chain, generating factual questions when more information is needed, and a low-level search agent that iteratively retrieves more information, refining its search based on intermediate findings. This design allows each agent to specialize in its respective task, enhancing verification accuracy and interpretability. HARIS is trained using reinforcement learning with outcome-based rewards. Experimental results on the EX-FEVER and HOVER benchmarks demonstrate that HARIS achieves strong performance, greatly advancing multi-hop claim verification.

Social reasoning - inferring unobservable beliefs and intentions from partial observations of other agents - remains a challenging task for large language models (LLMs). We evaluate the limits of current reasoning language models in the social deduction game Avalon and find that while the largest models demonstrate strong performance, they require extensive test-time inference and degrade sharply when distilled to smaller, real-time-capable variants. To address this, we introduce a hybrid reasoning framework that externalizes belief inference to a structured probabilistic model, while using an LLM for language understanding and interaction. Our approach achieves competitive performance with much larger models in Agent-Agent play and, notably, is the first language agent to defeat human players in a controlled study - achieving a 67% win rate and receiving higher qualitative ratings than both reasoning baselines and human teammates. We release code, models, and a dataset to support future work on social reasoning in LLM agents, which can be found at https://camp-lab-purdue.github.io/bayesian-social-deduction/

Chest X ray (CXR) imaging remains a critical diagnostic tool for thoracic conditions, but current automated systems face limitations in pathology coverage, diagnostic accuracy, and integration of visual and textual reasoning. To address these gaps, we propose RadFabric, a multi agent, multimodal reasoning framework that unifies visual and textual analysis for comprehensive CXR interpretation. RadFabric is built on the Model Context Protocol (MCP), enabling modularity, interoperability, and scalability for seamless integration of new diagnostic agents. The system employs specialized CXR agents for pathology detection, an Anatomical Interpretation Agent to map visual findings to precise anatomical structures, and a Reasoning Agent powered by large multimodal reasoning models to synthesize visual, anatomical, and clinical data into transparent and evidence based diagnoses. RadFabric achieves significant performance improvements, with near-perfect detection of challenging pathologies like fractures (1.000 accuracy) and superior overall diagnostic accuracy (0.799) compared to traditional systems (0.229 to 0.527). By integrating cross modal feature alignment and preference-driven reasoning, RadFabric advances AI-driven radiology toward transparent, anatomically precise, and clinically actionable CXR analysis.